Gender Differences in Fat Metabolism – Interesting. I have noted several times now that when I lose weight, it tends to come off my upper body (around the rib cage) first. And no matter what I do, I can’t seem to slim down my chunky thighs. It’s also very evident that my body tends to hold on to weight in general a lot more than the Snook’s. (His belly is almost gone!) MDA makes the case that this is natural and, if anything, means that my body is probably pretty healthy.